The present study deals with the formulation of fast dissolving tablets of poorly soluble carvedilol by direct compression technique using solid dispersion method and various superdisintegrants like croscaramellose sodium, sodium starch glycolate and crospovidone. The prepared tablets were evaluated for hardness, friability, drug content, weight variation, disintegration time, wetting time and in vitro dissolution studies. The prepared solid dispersion was subjected to DSC studies. No chemical interaction between drug and excipients was confirmed. SEM studies revealed the amorphous form of carvedilol in solid dispersion. The different formulations showed disintegration time between 64.16 and 74.12s. Among all the formulations F1 formulation containing croscaramellose sodium (9mg) showed release up to 98.67% in 12 min. Thus, F1 was considered as the best among the other formulations.
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